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Friday 27 November 2015

Tap water, salt makes cooked food toxic

19:22:00 0

Salt and tap water together unfit for cooking

Cooking with chloraminated tap water and iodised table salt could put potentially harmful toxins in your food, a study has warned. 


Researchers have found several molecules that are almost completely new to scientists, created by cooking with chloraminated tap water and iodised table salt. They said that limiting cooking time and temperature, and cooking with table salt fortified with iodate instead of iodide, could be safest.

These two processes -chlorination and chloramination -have an effect on the chemical make-up of the water. Chlorine or chloramines in tap water can react with the iodised table salt added to food, creating a kind of acid called hypoiodous acid.


The acid can then react with the food and other organic matter in the tap water to create cooking iodinated disinfection byproducts (IDBPs) -molecules that are new to researchers.

Our tap water is disinfected before we drink it or use it in cooking. This is done in several ways, including by adding chlorine or molecules called chloramines that are made using ammonia.

This in itself is not cause for concern, but the acid can then react with the food and other organic matter in the tap water to create cooking iodinated disinfection byproducts (I-DBPs) -- molecules that are almost completely new to researchers. For this study, researchers identified some molecules and tested their toxicity.
“I-DBPs formed during cooking with chloraminated or chlorinated tap water are something new to environmental chemists, toxicologists and engineers,” said Xiangru Zhang, corresponding author of the paper and Associate Professor at the Hong Kong University of Science and Technology. “They are relevant not only to drinking water researchers and practitioners but also to the public,” he added.
The researchers analysed the I-DBPs formed during cooking with chlorinated and chloraminated tap water. They simulated cooking with different types of tap water at varying temperatures and time, and added wheat flour and iodised salt to see what I-DBPs would be formed.
Using cutting-edge chemistry techniques, they identified 14 completely new molecules and determined the structure of nine molecules. They then carried out tests to see how toxic nine of the molecules are and found that some of the molecules are 50-200 times more toxic than others. The study was published in the journal Water Research.


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Thursday 26 November 2015

Pharm.D 3rd Year PREVIOUS QUESTION PAPERS-JNTU HYDERABAD

08:26:00 7
Pharm D THIRD YEAR EXAMINATION PREVIOUS QUESTION PAPERS-JNTU HYDERABAD


                                             Pharmacotherapeutics - II



Pharmacology - II



Pharmaceutical Analysis




Medicinal Chemistry




Pharmaceutical Jurisprudence




Pharmaceutical Formulations






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Monday 23 November 2015

Amazing Facts About The Human Body

23:42:00 0

Interesting facts about the human body


The human body is an incredibly complex and intricate system and it still baffles researchers regularly despite thousands of years of medical knowledge. As a result, it shouldn't be a surprise that even body parts we deal with everyday have unexpected facts and explanations behind them.

Here are 100 wacky facts about the human body:

1. The brain is more active at night than during the day. Scientists don't know yet why this is.

2. The higher your IQ, the more you dream.

3. Facial hair grows faster than any other hair on the body.

4. The nail on the middle finger grows faster than the other fingernails.

5. Fingernails grow nearly four times faster than toe nails.

6. The lifespan of a human hair is 3 to 7 years on average.

7. The acid in your stomach is strong enough to dissolve zinc. It doesn't destroy the stomach because because the stomach walls constantly renews itself.

8. Women's hearts beat faster than men's.

9. Women blink twice as many times as men do.

10. Women are born better smellers than men and remain better smellers over life.

11. Men burn fat faster than women by a rate of about 50 calories a day.

12. Men get hiccups more often than women.

13. A man has approximately 6.8 litres of blood in the body while women have approximately 5 litres.

14. The largest cell in the body is the female egg and the smallest is the male sperm.

15. During your lifetime, you will produce enough saliva to fill two swimming pools.

16. Babies are always born with blue eyes. The melanin in their eyes needs time to be fully deposited or to be darkened by ultraviolet light to reveal the baby's true eye color.

17. Men have erections every hour to hour and a half during sleep. This is because the combination of blood circulation and testerone production can cause erections during sleep and are a necessary part of REM sleep.

18. After eating too much, your hearing is less sharp.

19. If your saliva cannot dissolve or mix with food, you will not be able to taste that food (try tasting something after drying off your tongue)

20. Noise causes the pupils of your eyes to dilate. Even very small noises can do this.

21. Everyone has a unique smell, unique finger print and unique tongue print.

22. By age 60, most people will have lost half their taste buds.

23. Your eyes remain the same size after birth but your nose and ears never stop growing.

24. A simple, moderately severe sunburn burns the blood vessels extensively.

25. We are about 1cm taller in the mornings than in the evenings.

26. The strongest muscle in the body is the human tongue.

27. The hardest bone in the human body is the jaw bone.

28. The hands and feet contains almost half of the total bones in the human body.

29. About 32 million bacteria call every inch of your skin home, but they are mostly harmless and some of them are even helpful.

30. Humans shed and regrow outer skin every 27 days.

31. Three hundred million cells die in the human body every minute and everyday and adult produces 300 billion new cells.

32. The colder the room you sleep, the higher the chances are that you would get a nightmare.

33. Humans are the only species that produce emotional tears.

34. All babies are color blind at birth, they see only black and white.

35. The only part of your body that has no blood supply is the cornea in the eye. It gets its oxygen directly from air.

36. A normal human being can survive 20 days without eating but can survive only 2 days without drinking.

37. It is impossible to kill yourself by choking yourself with your hands.

38. Everybody has one strong eye and one weak eye.

39. Your skeleton keeps renewing itself every ten years which means that every ten years you get a new skeleton.

40. The human feet have 500,000 sweat glands and can produce more than a pint of sweat a day.

41. When you sneeze all body functions stop, even your heart.

42. Babies are born with 300 bones, but by adulthood the number is reduced to 206. 

43.  It takes 17 muscles to smile and 43 to frown.

44.  The tooth is the only part of the human body that can’t repair itself.

45.  Humans shed about 600,000 particles of skin every hour.

46.  The most common blood type in the world is Type O. The rarest blood type, A-H or Bombay blood due to the location of its discovery, has been found in less than hundred people since it was discovered.

47.  Human lips have a reddish color because of the great concentration of tiny capillaries just below the skin. 

48.  Tears and mucus contain an enzyme (lysozyme) that breaks down the cell wall of many bacteria.

49.  Women burn fat more slowly than men.

50.  Your eyes are always the same size from birth but your nose and ears never stop growing.




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Saturday 21 November 2015

GPAT Model Sample Question Paper with answers

11:58:00 1

1. Which of the following anti-arrhythmic drug is having Iodine?
  1. Disopyramide
  2. Flecainide
  3. Amiodarone
  4. Quinidine
Ans- 3

2. Two of the most serious are Stevens–Johnson syndrome and Toxic Epidermal Necrolysis (TEN or Lyell syndrome) common adverse effect associated with one of the following category of drugs..?

    1. Penicillins 

    2.  Tetracyclines

    3. Sulphonamides

    4.  Macrolides

Ans - 3

3. Which of the following ergot alkaloids is water soluble and shows blue fluorescence
     
    1. Ergosine 

    2. Ergotamine 

    3. Ergocristine

    4. Ergometrine

Ans - 4

 4. The quality of Coca leaves is mainly dependent on which of the following constituents?
  1. Cocaine
  2. Truxilline
  3. Ecgonine
  4. Cinnamyl cocaine
Ans - 3

5. Selective serotonin reuptake inhibitor is

    1. Imipramine

    2. Iproniazide

    3. Fluoxetin

    4. Naphazoline

Ans - 3

6.   The below reaction is an example for which of the following?
  1. Williamson reaction
  2. Clemmenson reaction
  3. Wuotz's reaction
  4. Reformatsky reaction
Ans - 1

7.Which of the following group is detected by using Herzig Meyer method?
  1. Alkyl group
  2. Hydroxy group
  3. Alkoxy group
  4. N-alkyl group
Ans - 4

8. Which of the following drug blocks the sodium channel and dissociates slowly?
  1. Quinidine
  2. Lignocaine
  3. Flecainide
  4. Procainamide
Ans - 3

9. According to Drugs and Cosmetics act, List of substances that should be sold by retail only on prescription of registered medical practitioner is given in which of the following Schedule?
  1. Schedule 'H'
  2. Schedule 'V'
  3. Schedule 'X'
  4. Schedule 'Q'
Ans - 1

10. Levodopa and carbidopa combination to treat

    1. Epilepsy

    2. Depression

    3. Parkinson

    4. Truma head injury

Ans -3

11. In HPLC, which pump gives a mobile phase flow rate dependent on column permeability?
  1. Constant pressure pumps
  2. Constant displacement pumps
  3. Reciprocating pumps
  4. Pneumatic pumps
Ans - 1

12. Which of the following organism is the Source for amphotericin?
  1. Streptomyces immodosus
  2. Streptomyces nodosus
  3. Streptomyces griseus
  4. Streptomyces aureofaciens
Ans - 2

13. Which of the following drug produces gastric irritation after micronization?
  1. Phenobarbital
  2. Tetracycline
  3. Erythromycin
  4. Nitrofurantoin
Ans - 4

14. Adult dose of a drug is 150 mg/kg and the drug is available as tablets of 2 mg strength. Calculate the dosed required for a boy of age 14 yrs and weight of 35 kg?
  1. 74.9 mg
  2. 78 mg
  3. 82 mg
  4. 80 mg
Ans - 1

15. Select the correction: combination of drugs for the treatment of patients suffering from Hep-C 
    1.  Interferon with Ribavirin

    2.  Interferon with Zidovudine

    3. Interferon with Stavudine

    4. Interferon with Lamivudine

Ans - 3

16. Which of the following method is used to measure respiratory efficiency of cells in cell culture?
  1. Fluroscein Diacetate method
  2. Reduction of tetrazolium salts
  3. Evan's blue method
  4. Calcofluor white method
Ans - 2

17. Which of the following Dopaminergic agonist used in the treatment of Parkinsonism?
  1. Levodopa
  2. Carbidopa
  3. Mirtazapine
  4. Ropinirole
Ans - 4

18. What is the principle involved in the VDRL test?
  1. Agglutination
  2. Precipitation
  3. Flocculation
  4. Opsonisation
Ans - 2

19. Prazocine is a derivative of which of the following?
  1. Quinazoline
  2. Phthalazine
  3. Quinoline
  4. Isoquinoline
Ans -1

20. The area under the serum concentration versus time curve represents

    1.  Biological half of drug

    2. Amount of drug cleared by kidneys

    3. Amount of drug in original dosage form 

    4. Amount of drug absorbed

Ans -1

21. Bladder toxicity is the side effect of which of the following drug?
  1. Vincristine
  2. Cyclophosphamide
  3. 5-Flouro Uracil
  4. Doxorubicin
Ans - 2

22. Which of the following is a prototype of Sedative?
  1. Chloral hydrate
  2. Chloral
  3. Chloroquine
  4. Chlorpheniramie
Ans - 2

23. If the half life for decomposition of a drug is 12 hrs, how long will it take for 125 mg of the drug to decompose by 30 %? Assume that the drug follows first order kinetics at constant temperature.
  1. 6.1 hr
  2. 8.2 hr
  3. 7.9 hr
  4. 5.5 hr
Ans - 1

24. Which of the following is used as Cuticle Remover?
  1. Nitrocellulose
  2. Mineral oil
  3. Trisodium phosphate
  4. Acetoglyceride
Ans - 3

25. Which of the following amino acid is present in Captopril?
  1. Glycine
  2. Cysteine
  3. Proline
  4. Para Amino benzoic acid
Ans - 3

 26.  Aconitine on hydrolysis gives

  1.  Benzoic acid + Acetic acid + Aconine

  2. Cinnamic acid + Tropic acid + Aconine
  
  3. Cinnamic acid + Methyl alcohol + Benzoyl Aconine

  4. Formic acid + Methyl alcohol + Benzoyl Aconine

Ans - 1

27. Sulfonamides are effective against:

  1.  Bacteria and Chlamidia

  2. Actinomyces

  3. Protozoa

  4. All of the above

Ans - 1

28. The onset of pharmacological response of a drug depends on which of the following Pharmacokinetic parameter?

  1. Absorption

  2.  Metabolism

  3. Protein binding

  4. All the above

Ans - 4

29. Streptomycin side effect

  1. Nephrotoxic

  2. Ototoxic

  3. Grey baby syndrome

  4. Both A&B

Ans - 4

30. The plasma drug concentration versus time plot is useful in determination of which of the following parameter

  1. Distribution

  2. Bioavailabity

  3. Metabolism

  4. All the above

Ans -2


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Prepared by:
S.Seetaramswamy, M.Pharm.,
Asst.Professor

CBCP
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