GPAT Model Sample Question Paper with answers

GPAT Model Question Paper with answers

1. Which of the following anti-arrhythmic drug is having Iodine?

1. Disopyramide
2. Flecainide
3. Amiodarone
4. Quinidine

Ans- 3

2. Two of the most serious are Stevens–Johnson syndrome and Toxic Epidermal Necrolysis (TEN or Lyell syndrome) common adverse effect associated with one of the following category of drugs..?

    1. Penicillins 

    2.  Tetracyclines

    3. Sulphonamides

    4.  Macrolides

Ans - 3

3. Which of the following ergot alkaloids is water soluble and shows blue fluorescence

     

    1. Ergosine 

    2. Ergotamine 

    3. Ergocristine

    4. Ergometrine

Ans - 4

 4. The quality of Coca leaves is mainly dependent on which of the following constituents?

1. Cocaine
2. Truxilline
3. Ecgonine
4. Cinnamyl cocaine

Ans - 3

5. Selective serotonin reuptake inhibitor is

    1. Imipramine

    2. Iproniazide

    3. Fluoxetin

    4. Naphazoline

Ans - 3

6.   The below reaction is an example for which of the following?

1. Williamson reaction
2. Clemmenson reaction
3. Wuotz's reaction
4. Reformatsky reaction

Ans - 1

7.Which of the following group is detected by using Herzig Meyer method?

1. Alkyl group
2. Hydroxy group
3. Alkoxy group
4. N-alkyl group

Ans - 4

8. Which of the following drug blocks the sodium channel and dissociates slowly?

1. Quinidine
2. Lignocaine
3. Flecainide
4. Procainamide

Ans - 3

9. According to Drugs and Cosmetics act, List of substances that should be sold by retail only on prescription of registered medical practitioner is given in which of the following Schedule?

1. Schedule 'H'
2. Schedule 'V'
3. Schedule 'X'
4. Schedule 'Q'

Ans - 1

10. Levodopa and carbidopa combination to treat

    1. Epilepsy

    2. Depression

    3. Parkinson

    4. Truma head injury

Ans -3

11. In HPLC, which pump gives a mobile phase flow rate dependent on column permeability?

1. Constant pressure pumps
2. Constant displacement pumps
3. Reciprocating pumps
4. Pneumatic pumps

Ans - 1

12. Which of the following organism is the Source for amphotericin?

1. Streptomyces immodosus
2. Streptomyces nodosus
3. Streptomyces griseus
4. Streptomyces aureofaciens

Ans - 2

13. Which of the following drug produces gastric irritation after micronization?

1. Phenobarbital
2. Tetracycline
3. Erythromycin
4. Nitrofurantoin

Ans - 4

14. Adult dose of a drug is 150 mg/kg and the drug is available as tablets of 2 mg strength. Calculate the dosed required for a boy of age 14 yrs and weight of 35 kg?

1. 74.9 mg
2. 78 mg
3. 82 mg
4. 80 mg

Ans - 1

15. Select the correction: combination of drugs for the treatment of patients suffering from Hep-C 

    1.  Interferon with Ribavirin

    2.  Interferon with Zidovudine

    3. Interferon with Stavudine

    4. Interferon with Lamivudine

Ans - 3

16. Which of the following method is used to measure respiratory efficiency of cells in cell culture?

1. Fluroscein Diacetate method
2. Reduction of tetrazolium salts
3. Evan's blue method
4. Calcofluor white method

Ans - 2

17. Which of the following Dopaminergic agonist used in the treatment of Parkinsonism?

1. Levodopa
2. Carbidopa
3. Mirtazapine
4. Ropinirole

Ans - 4

18. What is the principle involved in the VDRL test?

1. Agglutination
2. Precipitation
3. Flocculation
4. Opsonisation

Ans - 2

19. Prazocine is a derivative of which of the following?

1. Quinazoline
2. Phthalazine
3. Quinoline
4. Isoquinoline

Ans -1

20. The area under the serum concentration versus time curve represents

    1.  Biological half of drug

    2. Amount of drug cleared by kidneys

    3. Amount of drug in original dosage form 

    4. Amount of drug absorbed

Ans -1

21. Bladder toxicity is the side effect of which of the following drug?

1. Vincristine
2. Cyclophosphamide
3. 5-Flouro Uracil
4. Doxorubicin

Ans - 2

22. Which of the following is a prototype of Sedative?

1. Chloral hydrate
2. Chloral
3. Chloroquine
4. Chlorpheniramie

Ans - 2

23. If the half life for decomposition of a drug is 12 hrs, how long will it take for 125 mg of the drug to decompose by 30 %? Assume that the drug follows first order kinetics at constant temperature.

1. 6.1 hr
2. 8.2 hr
3. 7.9 hr
4. 5.5 hr

Ans - 1

24. Which of the following is used as Cuticle Remover?

1. Nitrocellulose
2. Mineral oil
3. Trisodium phosphate
4. Acetoglyceride

Ans - 3

25. Which of the following amino acid is present in Captopril?

1. Glycine
2. Cysteine
3. Proline
4. Para Amino benzoic acid

Ans - 3

 26.  Aconitine on hydrolysis gives

  1.  Benzoic acid + Acetic acid + Aconine

  2. Cinnamic acid + Tropic acid + Aconine

  

  3. Cinnamic acid + Methyl alcohol + Benzoyl Aconine

  4. Formic acid + Methyl alcohol + Benzoyl Aconine

Ans - 1

27. Sulfonamides are effective against:

  1.  Bacteria and Chlamidia

  2. Actinomyces

  3. Protozoa

  4. All of the above

Ans - 1

28. The onset of pharmacological response of a drug depends on which of the following Pharmacokinetic parameter?

  1. Absorption

  2.  Metabolism

  3. Protein binding

  4. All the above

Ans - 4

29. Streptomycin side effect

  1. Nephrotoxic

  2. Ototoxic

  3. Grey baby syndrome

  4. Both A&B

Ans - 4

30. The plasma drug concentration versus time plot is useful in determination of which of the following parameter

  1. Distribution

  2. Bioavailabity

  3. Metabolism

  4. All the above

Ans -2

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Prepared by:

S.Seetaramswamy, M.Pharm.,

Asst.Professor

CBCP